Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

Enhancing the functional uptake of antisense oligonucleotide (ASO) in the muscle will be beneficial for developing ASO therapeutics targeting genes expressed in the muscle. We hypothesized that improving albumin binding will facilitate traversal of ASO from the blood compartment to the interstitium...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Prakash, Thazha P, Mullick, Adam E, Lee, Richard G, Yu, Jinghua, Yeh, Steve T, Low, Audrey, Chappell, Alfred E, Østergaard, Michael E, Murray, Sue, Gaus, Hans J, Swayze, Eric E, Seth, Punit P
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
Assuntos:
Chemical Biology and Nucleic Acid Chemistry
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6614804/
https://ncbi.nlm.nih.gov/pubmed/31127296
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz354
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares