Structural analysis of human Argonaute-2 bound to a modified siR-NA guide

Incorporation of chemical modifications into small interfering RNAs (siRNAs) increases metabolic stability and improves tissue distribution. However, how these modifications impact interactions with Argonaute-2 (Ago2), the molecular target of siRNAs, is not known. Herein, we present the crystal stru...

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Udgivet i:J Am Chem Soc
Main Authors: Schirle, Nicole T., Kinberger, Garth A., Murray, Heather F., Lima, Walt F., Prakash, Thazha P., MacRae, Ian J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4993527/
https://ncbi.nlm.nih.gov/pubmed/27380263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b04454
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