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Structural analysis of human Argonaute-2 bound to a modified siR-NA guide
Incorporation of chemical modifications into small interfering RNAs (siRNAs) increases metabolic stability and improves tissue distribution. However, how these modifications impact interactions with Argonaute-2 (Ago2), the molecular target of siRNAs, is not known. Herein, we present the crystal stru...
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| Udgivet i: | J Am Chem Soc |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4993527/ https://ncbi.nlm.nih.gov/pubmed/27380263 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b04454 |
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