Structure-Guided Control of siRNA Off-Target Effects

Short interfering RNAs (siRNAs) are promising therapeutics that make use of the RNA interference (RNAi) pathway, but liabilities arising from the native RNA structure necessitate chemical modification for drug development. Advances in the structural characterization of components of the human RNAi p...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Suter, Scott R., Sheu-Gruttadauria, Jessica, Schirle, Nicole T., Valenzuela, Rachel, Ball-Jones, Alexi A., Onizuka, Kazumitsu, MacRae, Ian J., Beal, Peter A.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4962782/
https://ncbi.nlm.nih.gov/pubmed/27387838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b06137
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