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Controlling miRNA-like Off-target Effects of an siRNA with Nucleobase Modifications
SiRNAs can cause unintended gene silencing due to miRNA-like effects because of the similarity in function of an siRNA guide strand and a miRNA. Here we evaluate the effect on miRNA-like off targeting of introducing the adenosine derivative 7-EAA and triazoles prepared from 7-EAA at different positi...
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| Publicado no: | Org Biomol Chem |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5734094/ https://ncbi.nlm.nih.gov/pubmed/29164215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob02654d |
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