Controlling miRNA-like Off-target Effects of an siRNA with Nucleobase Modifications

SiRNAs can cause unintended gene silencing due to miRNA-like effects because of the similarity in function of an siRNA guide strand and a miRNA. Here we evaluate the effect on miRNA-like off targeting of introducing the adenosine derivative 7-EAA and triazoles prepared from 7-EAA at different positi...

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Bibliografske podrobnosti
izdano v:Org Biomol Chem
Main Authors: Suter, Scott R., Ball-Jones, Alexi, Mumbleau, Madeline M., Valenzuela, Rachel, Ibarra-Soza, Jose, Owens, Hassan, Fisher, Andrew J., Beal, Peter A.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5734094/
https://ncbi.nlm.nih.gov/pubmed/29164215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob02654d
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