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7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove()
Here we describe the synthesis of new 7-substituted 8-aza-7-deazaadenosine ribonucleoside phosphoramidites and their use in generating major groove-modified duplex RNAs. A 7-ethynyl analog leads to further structural diversification of the RNA via post-automated RNA synthesis azide/alkyne cycloaddit...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3417767/ https://ncbi.nlm.nih.gov/pubmed/22766576 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2ob25647a |
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