7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove()

Here we describe the synthesis of new 7-substituted 8-aza-7-deazaadenosine ribonucleoside phosphoramidites and their use in generating major groove-modified duplex RNAs. A 7-ethynyl analog leads to further structural diversification of the RNA via post-automated RNA synthesis azide/alkyne cycloaddit...

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Detaylı Bibliyografya
Asıl Yazarlar: Ibarra-Soza, José M., Morris, Alexi A., Jayalath, Prasanna, Peacock, Hayden, Conrad, Wayne E., Donald, Michael B., Kurth, Mark J., Beal, Peter A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
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Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417767/
https://ncbi.nlm.nih.gov/pubmed/22766576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c2ob25647a
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