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Minor-groove-modulating adenosine replacements control protein binding and RNAi activity in siRNAs
Short-interfering RNAs (siRNAs) are common tools in molecular biology, however the development of RNAi-based therapeutics is limited by immunostimulatory and non-specific effects mediated by off-target RNA-binding proteins. PKR and ADAR1 are two proteins implicated in RNAi off-target effects, and sh...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3003776/ https://ncbi.nlm.nih.gov/pubmed/20863128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb100245u |
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