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8-Oxoguanosine Switches Modulate the Activity of Alkylated siRNAs by Controlling Steric Effects in the Major vs. Minor Grooves
Small interfering double-stranded RNAs have been synthesized bearing one or more base modifications at nucleotide positions 4, 11 and/or 16 in the guide strand. The chemically modified base is an N(2)-alkyl-8-oxo-7,8-dihydroguanine (alkyl = propyl, benzyl) that can alternatively pair in a Watson-Cri...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3086133/ https://ncbi.nlm.nih.gov/pubmed/21452817 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2003878 |
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