Minor groove DNA alkylation directed by major groove triplex forming oligodeoxyribonucleotides.

We describe sequence-specific alkylation in the minor groove of double-stranded DNA by a hybridization-triggered reactive group conjugated to a triplex forming oligodeoxyribonucleotide (TFO) that binds in the major groove. The 24 nt TFOs (G/A motif) were designed to form triplexes with a homopurine...

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Detalhes bibliográficos
Main Authors: Lukhtanov, E A, Mills, A G, Kutyavin, I V, Gorn, V V, Reed, M W, Meyer, R B
Formato: Artigo
Idioma:Inglês
Publicado em: 1997
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC147161/
https://ncbi.nlm.nih.gov/pubmed/9396819
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