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Factors influencing the extent and selectivity of alkylation within triplexes by reactive G/A motif oligonucleotides.

G/A motif triplex-forming oligonucleotides (TFOs) complementary to a 21 base pair homopurine/homopyrimidine run were conjugated at one or both ends to chlorambucil. These TFOs were incubated with several synthetic duplexes containing the targeted homopurine run flanked by different sequences. The ex...

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Udgivet i:Nucleic Acids Res
Principais autores: Lampe, J N, Kutyavin, I V, Rhinehart, R, Reed, M W, Meyer, R B, Gamper, H B
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC146991/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9321668/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.20.4123
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