Factors influencing the extent and selectivity of alkylation within triplexes by reactive G/A motif oligonucleotides.

G/A motif triplex-forming oligonucleotides (TFOs) complementary to a 21 base pair homopurine/homopyrimidine run were conjugated at one or both ends to chlorambucil. These TFOs were incubated with several synthetic duplexes containing the targeted homopurine run flanked by different sequences. The ex...

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Detalles Bibliográficos
Main Authors: Lampe, J N, Kutyavin, I V, Rhinehart, R, Reed, M W, Meyer, R B, Gamper, H B
Formato: Artigo
Idioma:Inglês
Publicado: 1997
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC146991/
https://ncbi.nlm.nih.gov/pubmed/9321668
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