Minor groove DNA alkylation directed by major groove triplex forming oligodeoxyribonucleotides.

We describe sequence-specific alkylation in the minor groove of double-stranded DNA by a hybridization-triggered reactive group conjugated to a triplex forming oligodeoxyribonucleotide (TFO) that binds in the major groove. The 24 nt TFOs (G/A motif) were designed to form triplexes with a homopurine...

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Publicado en:	Nucleic Acids Res
Autores principales:	Lukhtanov, E A, Mills, A G, Kutyavin, I V, Gorn, V V, Reed, M W, Meyer, R B
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Oxford University Press 1997
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147161/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9396819/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.24.5077
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