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Minor groove DNA alkylation directed by major groove triplex forming oligodeoxyribonucleotides.

We describe sequence-specific alkylation in the minor groove of double-stranded DNA by a hybridization-triggered reactive group conjugated to a triplex forming oligodeoxyribonucleotide (TFO) that binds in the major groove. The 24 nt TFOs (G/A motif) were designed to form triplexes with a homopurine...

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Sonraí Bibleagrafaíochta
Main Authors: Lukhtanov, E A, Mills, A G, Kutyavin, I V, Gorn, V V, Reed, M W, Meyer, R B
Formáid: Artigo
Teanga:Inglês
Foilsithe: 1997
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC147161/
https://ncbi.nlm.nih.gov/pubmed/9396819
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