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Guide Strand 3′-End Modifications Regulate siRNA Specificity
Short interfering RNA (siRNA)-triggered gene knockdown via the RNA interference (RNAi) pathway is widely used to study gene function and siRNA-based therapeutics are in development. However, since the guide strand of an siRNA can function like a natural microRNA (miRNA), siRNAs often repress hundred...
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| 發表在: | Chembiochem |
|---|---|
| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5161629/ https://ncbi.nlm.nih.gov/pubmed/27731539 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600453 |
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