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siRNA potency enhancement via chemical modifications of nucleotide bases at the 5′-end of the siRNA guide strand
Small interfering RNAs (siRNAs) can be utilized not only as functional biological research tools but also as therapeutic agents. For the clinical use of siRNA as drugs, various chemical modifications have been used to improve the activity of siRNA drugs, and further chemical modifications are expect...
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| Publicado en: | RNA |
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| Main Authors: | , , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7812868/ https://ncbi.nlm.nih.gov/pubmed/33177188 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.073783.119 |
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