siRNA potency enhancement via chemical modifications of nucleotide bases at the 5′-end of the siRNA guide strand

Small interfering RNAs (siRNAs) can be utilized not only as functional biological research tools but also as therapeutic agents. For the clinical use of siRNA as drugs, various chemical modifications have been used to improve the activity of siRNA drugs, and further chemical modifications are expect...

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Bibliografiske detaljer
Udgivet i:RNA
Main Authors: Shinohara, Fumikazu, Oashi, Taiji, Harumoto, Toshimasa, Nishikawa, Tomoyuki, Takayama, Yuki, Miyagi, Hikaru, Takahashi, Yuichi, Nakajima, Takahiro, Sawada, Takashi, Koda, Yasuo, Makino, Asana, Sato, Atsuko, Hamaguchi, Kaori, Suzuki, Michihiko, Yamamoto, Junichiro, Tomari, Yukihide, Saito, Jun-Ichi
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7812868/
https://ncbi.nlm.nih.gov/pubmed/33177188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.073783.119
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