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Guide Strand 3′-End Modifications Regulate siRNA Specificity

Short interfering RNA (siRNA)-triggered gene knockdown via the RNA interference (RNAi) pathway is widely used to study gene function and siRNA-based therapeutics are in development. However, since the guide strand of an siRNA can function like a natural microRNA (miRNA), siRNAs often repress hundred...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Chembiochem
Egile Nagusiak: Valenzuela, Rachel, Onizuka, Kazumitsu, Ball-Jones, Alexi A., Hu, Tiannan, Suter, Scott, Beal, Peter A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5161629/
https://ncbi.nlm.nih.gov/pubmed/27731539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201600453
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