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Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets

MicroRNAs (miRNAs) direct post-transcriptional regulation of human genes by guiding Argonaute proteins to complementary sites in messenger RNAs (mRNAs) targeted for repression. An enigmatic feature of many conserved mammalian miRNA target sites is that an adenosine (A) nucleotide opposite miRNA nucl...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Schirle, Nicole T, Sheu-Gruttadauria, Jessica, Chandradoss, Stanley D, Joo, Chirlmin, MacRae, Ian J
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2015
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4606517/
https://ncbi.nlm.nih.gov/pubmed/26359634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07646
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