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Helix‐7 in Argonaute2 shapes the microRNA seed region for rapid target recognition

Argonaute proteins use microRNAs (miRNAs) to identify mRNAs targeted for post‐transcriptional repression. Biochemical assays have demonstrated that Argonaute functions by modulating the binding properties of its miRNA guide so that pairing to the seed region is exquisitely fast and accurate. However...

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Bibliografiske detaljer
Udgivet i:EMBO J
Main Authors: Klum, Shannon M, Chandradoss, Stanley D, Schirle, Nicole T, Joo, Chirlmin, MacRae, Ian J
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5753032/
https://ncbi.nlm.nih.gov/pubmed/28939659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201796474
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