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mRNA structural dynamics shape Argonaute-target interactions
small interfering RNAs (siRNAs) promote RNA degradation in a variety of processes and have important clinical applications. siRNAs direct cleavage of target RNAs by guiding Argonaute2 (AGO2) to its target site. Target site accessibility is critical for AGO2-target interactions, but how target site a...
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| 發表在: | Nat Struct Mol Biol |
|---|---|
| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2020
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8210632/ https://ncbi.nlm.nih.gov/pubmed/32661421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41594-020-0461-1 |
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