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Efficient and specific knockdown of small non-coding RNAs in mammalian cells and in mice

Hundreds of small nuclear non-coding RNAs, including small nucleolar RNAs (snoRNAs), have been identified in different organisms, with important implications in regulating gene expression and in human diseases. However, functionalizing these nuclear RNAs in mammalian cells remains challenging, due t...

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Autori principali: Liang, Xue-hai, Vickers, Timothy A., Guo, Shuling, Crooke, Stanley T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3035437/
https://ncbi.nlm.nih.gov/pubmed/21062825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq1121
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