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Efficient and specific gene knockdown by small interfering RNAs produced in bacteria

Synthetic small interfering RNAs (siRNAs) are an indispensable tool to investigate gene function in eukaryotic cells(1,2) and may be used for therapeutic purposes to knockdown genes implicated in disease(3). Thus far, most synthetic siRNAs have been produced by chemical synthesis. Here we present a...

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Detaylı Bibliyografya
Asıl Yazarlar: Huang, Linfeng, Jin, Jingmin, Deighan, Padraig, Kiner, Evgeny, McReynolds, Larry, Lieberman, Judy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622153/
https://ncbi.nlm.nih.gov/pubmed/23475073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2537
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