Efficient and specific gene knockdown by small interfering RNAs produced in bacteria

Synthetic small interfering RNAs (siRNAs) are an indispensable tool to investigate gene function in eukaryotic cells(1,2) and may be used for therapeutic purposes to knockdown genes implicated in disease(3). Thus far, most synthetic siRNAs have been produced by chemical synthesis. Here we present a...

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Bibliografiske detaljer
Main Authors: Huang, Linfeng, Jin, Jingmin, Deighan, Padraig, Kiner, Evgeny, McReynolds, Larry, Lieberman, Judy
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3622153/
https://ncbi.nlm.nih.gov/pubmed/23475073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2537
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