Prelamin A and lamin A appear to be dispensable in the nuclear lamina

Lamin A and lamin C, both products of Lmna, are key components of the nuclear lamina. In the mouse, a deficiency in both lamin A and lamin C leads to slow growth, muscle weakness, and death by 6 weeks of age. Fibroblasts deficient in lamins A and C contain misshapen and structurally weakened nuclei,...

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Detalhes bibliográficos
Main Authors: Fong, Loren G., Ng, Jennifer K., Lammerding, Jan, Vickers, Timothy A., Meta, Margarita, Coté, Nathan, Gavino, Bryant, Qiao, Xin, Chang, Sandy Y., Young, Stephanie R., Yang, Shao H., Stewart, Colin L., Lee, Richard T., Bennett, C. Frank, Bergo, Martin O., Young, Stephen G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2006
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1386109/
https://ncbi.nlm.nih.gov/pubmed/16511604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27125
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