Prelamin A and lamin A appear to be dispensable in the nuclear lamina

Lamin A and lamin C, both products of Lmna, are key components of the nuclear lamina. In the mouse, a deficiency in both lamin A and lamin C leads to slow growth, muscle weakness, and death by 6 weeks of age. Fibroblasts deficient in lamins A and C contain misshapen and structurally weakened nuclei,...

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Autors principals: Fong, Loren G., Ng, Jennifer K., Lammerding, Jan, Vickers, Timothy A., Meta, Margarita, Coté, Nathan, Gavino, Bryant, Qiao, Xin, Chang, Sandy Y., Young, Stephanie R., Yang, Shao H., Stewart, Colin L., Lee, Richard T., Bennett, C. Frank, Bergo, Martin O., Young, Stephen G.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2006
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1386109/
https://ncbi.nlm.nih.gov/pubmed/16511604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27125
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