Small interfering RNAs containing full 2′-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity

by KRAYNACK, BRYAN A., BAKER, BRENDA F.
Published 2006

Clinical and Preclinical Pharmacokinetics and Pharmacodynamics of Mipomersen (Kynamro(®)): A Second-Generation Antisense Oligonucleotide Inhibitor of Apolipoprotein B

by Geary, Richard S., Baker, Brenda F., Crooke, Stanley T.
Published in Clin Pharmacokinet (2015)

Phosphorothioate Antisense Oligonucleotides Induce the Formation of Nuclear Bodies

by Lorenz, Peter, Baker, Brenda F., Bennett, C. Frank, Spector, David L.
Published 1998

Antisense technology: A review

by Crooke, Stanley T., Liang, Xue-Hai, Baker, Brenda F., Crooke, Rosanne M.
Published in J Biol Chem (2021)

Nucleocytoplasmic shuttling: a novel in vivo property of antisense phosphorothioate oligodeoxynucleotides

by Lorenz, Peter, Misteli, Tom, Baker, Brenda F., Bennett, C. Frank, Spector, David L.
Published 2000

Enhancement of SMN2 Exon 7 Inclusion by Antisense Oligonucleotides Targeting the Exon

by Hua, Yimin, Vickers, Timothy A, Baker, Brenda F, Bennett, C. Frank, Krainer, Adrian R
Published 2007

Antisense Technology: An Emerging Platform for Cardiovascular Disease Therapeutics

by Lee, Richard G., Crosby, Jeff, Baker, Brenda F., Graham, Mark J., Crooke, Rosanne M.
Published 2013

Changes in Mipomersen Dosing Regimen Provide Similar Exposure With Improved Tolerability in Randomized Placebo‐Controlled Study of Healthy Volunteers

by Flaim, JoAnn D., Grundy, John S., Baker, Brenda F., McGowan, Mary P., Kastelein, John J. P.
Published 2014

Integrated Assessment of the Clinical Performance of GalNAc(3)-Conjugated 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides: I. Human Volunteer Experience

by Crooke, Stanley T., Baker, Brenda F., Xia, Shuting, Yu, Rosie Z., Viney, Nicholas J., Wang, Yanfeng, Tsimikas, Sotirios, Geary, Richard S.
Published in Nucleic Acid Ther (2019)

The Effects of 2′-O-Methoxyethyl Oligonucleotides on Renal Function in Humans

by Crooke, Stanley T., Baker, Brenda F., Pham, Nguyen C., Hughes, Steven G., Kwoh, T. Jesse, Cai, Danlin, Tsimikas, Sotirios, Geary, Richard S., Bhanot, Sanjay
Published in Nucleic Acid Ther (2018)

Effects of an Antisense Oligonucleotide Inhibitor of C‐Reactive Protein Synthesis on the Endotoxin Challenge Response in Healthy Human Male Volunteers

by Noveck, Robert, Stroes, Erik S. G., Flaim, JoAnn D., Baker, Brenda F., Hughes, Steve, Graham, Mark J., Crooke, Rosanne M., Ridker, Paul M
Published in J Am Heart Assoc (2014)

The Effects of 2′-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials

by Crooke, Stanley T., Baker, Brenda F., Witztum, Joseph L., Kwoh, T. Jesse, Pham, Nguyen C., Salgado, Nelson, McEvoy, Bradley W., Cheng, Wei, Hughes, Steven G., Bhanot, Sanjay, Geary, Richard S.
Published in Nucleic Acid Ther (2017)

A Selective Inhibitor of Human C-reactive Protein Translation Is Efficacious In Vitro and in C-reactive Protein Transgenic Mice and Humans

by Jones, Nicholas R, Pegues, Melissa A, McCrory, Mark A, Singleton, Walter, Bethune, Claudette, Baker, Brenda F, Norris, Daniel A, Crooke, Rosanne M, Graham, Mark J, Szalai, Alexander J
Published 2012

Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers

by Crooke, Stanley T, Baker, Brenda F, Kwoh, T Jesse, Cheng, Wei, Schulz, Dan J, Xia, Shuting, Salgado, Nelson, Bui, Huynh-Hoa, Hart, Christopher E, Burel, Sebastien A, Younis, Husam S, Geary, Richard S, Henry, Scott P, Bhanot, Sanjay
Published in Mol Ther (2016)

mNIS+7 and lower limb function in inotersen treatment of hereditary transthyretin‐mediated amyloidosis

by Dyck, P. James B., Kincaid, John C., Wiesman, Janice F., Polydefkis, Michael, Litchy, William J., Mauermann, Michelle L., Ackermann, Elizabeth J., Guthrie, Spencer, Pollock, Michael, Jung, Shiangtung W., Baker, Brenda F., Dyck, Peter J.
Published in Muscle Nerve (2020)

Mipomersen, an apolipoprotein B synthesis inhibitor, lowers low-density lipoprotein cholesterol in high-risk statin-intolerant patients: a randomized, double-blind, placebo-control...

by Visser, Maartje E., Wagener, Gilbert, Baker, Brenda F., Geary, Richard S., Donovan, Joanne M., Beuers, Ulrich H.W., Nederveen, Aart J., Verheij, Joanne, Trip, Mieke D., Basart, Dick C.G., Kastelein, John J.P., Stroes, Erik S.G.
Published 2012

IONIS-PKK(Rx) a Novel Antisense Inhibitor of Prekallikrein and Bradykinin Production

by Ferrone, Jason D., Bhattacharjee, Gourab, Revenko, Alexey S., Zanardi, Thomas A., Warren, Marshelle S., Derosier, Frederick J., Viney, Nicholas J., Pham, Nguyen C., Kaeser, Gwendolyn E., Baker, Brenda F., Schneider, Eugene, Hughes, Steven G., Monia, Brett P., MacLeod, A. Robert
Published in Nucleic Acid Ther (2019)

Ligand conjugated antisense oligonucleotide for the treatment of transthyretin amyloidosis: preclinical and phase 1 data

by Viney, Nicholas J., Guo, Shuling, Tai, Li‐Jung, Baker, Brenda F., Aghajan, Mariam, Jung, Shiangtung W., Yu, Rosie Z., Booten, Sheri, Murray, Heather, Machemer, Todd, Burel, Sebastien, Murray, Sue, Buchele, Gustavo, Tsimikas, Sotirios, Schneider, Eugene, Geary, Richard S., Benson, Merrill D., Monia, Brett P.
Published in ESC Heart Fail (2020)

Neuropathy symptom and change: Inotersen treatment of hereditary transthyretin amyloidosis

by Dyck, P. James B., Coelho, Teresa, Waddington Cruz, Marcia, Brannagan, Thomas H., Khella, Sami, Karam, Chafic, Berk, John L., Polydefkis, Michael J., Kincaid, John C., Wiesman, Janice F., Litchy, William J., Mauermann, Michelle L., Ackermann, Elizabeth J., Baker, Brenda F., Jung, Shiangtung W., Guthrie, Spencer, Pollock, Michael, Dyck, Peter J.
Published in Muscle Nerve (2020)