The Effects of 2′-O-Methoxyethyl Containing Antisense Oligonucleotides on Platelets in Human Clinical Trials

A thorough analysis of clinical trial data in the Ionis integrated safety database (ISDB) was performed to determine if there is a class effect on platelet numbers and function in subjects treated with 2′-O-methoxyethyl (2′MOE)-modified antisense oligonucleotides (ASOs). The Ionis ISDB includes over...

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Bibliografiske detaljer
Udgivet i:Nucleic Acid Ther
Main Authors: Crooke, Stanley T., Baker, Brenda F., Witztum, Joseph L., Kwoh, T. Jesse, Pham, Nguyen C., Salgado, Nelson, McEvoy, Bradley W., Cheng, Wei, Hughes, Steven G., Bhanot, Sanjay, Geary, Richard S.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2017
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5467133/
https://ncbi.nlm.nih.gov/pubmed/28145801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2016.0650
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