The Effects of 2′-O-Methoxyethyl Oligonucleotides on Renal Function in Humans

Systemically administered 2′-O-methoxyethyl (2′MOE) antisense oligonucleotides (ASOs) accumulate in the kidney and metabolites are cleared in urine. The effects of eleven 2′MOE ASOs on renal function were assessed in 2,435 patients from 32 phase 2 and phase 3 trials. The principle analysis was on da...

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Detalhes bibliográficos
Publicado no:Nucleic Acid Ther
Main Authors: Crooke, Stanley T., Baker, Brenda F., Pham, Nguyen C., Hughes, Steven G., Kwoh, T. Jesse, Cai, Danlin, Tsimikas, Sotirios, Geary, Richard S., Bhanot, Sanjay
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2018
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790433/
https://ncbi.nlm.nih.gov/pubmed/29185862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2017.0693
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