The Effects of 2′-O-Methoxyethyl Oligonucleotides on Renal Function in Humans

Systemically administered 2′-O-methoxyethyl (2′MOE) antisense oligonucleotides (ASOs) accumulate in the kidney and metabolites are cleared in urine. The effects of eleven 2′MOE ASOs on renal function were assessed in 2,435 patients from 32 phase 2 and phase 3 trials. The principle analysis was on da...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:Nucleic Acid Ther
Autores principales: Crooke, Stanley T., Baker, Brenda F., Pham, Nguyen C., Hughes, Steven G., Kwoh, T. Jesse, Cai, Danlin, Tsimikas, Sotirios, Geary, Richard S., Bhanot, Sanjay
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2018
Materias:
Original Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5790433/
https://ncbi.nlm.nih.gov/pubmed/29185862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2017.0693
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares