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Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers
The common chemical and biological properties of antisense oligonucleotides provide the opportunity to identify and characterize chemical class effects across species. The chemical class that has proven to be the most versatile and best characterized is the 2′-O-methoxyethyl chimeric antisense oligo...
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Publicat a: | Mol Ther |
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Autors principals: | , , , , , , , , , , , , , |
Format: | Artigo |
Idioma: | Inglês |
Publicat: |
Nature Publishing Group
2016
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Matèries: | |
Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5112040/ https://ncbi.nlm.nih.gov/pubmed/27357629 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.136 |
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