Lack of QT Prolongation for 2′-O-Methoxyethyl-Modified Antisense Oligonucleotides Based on Retrospective Exposure/Response Analysis of Ten Phase 1 Dose-Escalation Placebo-Controlle...

Por Yu, Rosie Z., Gunawan, Rudy, Geary, Richard S., Hughes, Steven G., Henry, Scott P., Wang, Yanfeng
Publicado no Nucleic Acid Ther (2017)

Antisense Oligonucleotide Therapy in Diabetic Retinopathy

Por Hnik, Peter, Boyer, David S., Grillone, Lisa R., Clement, John G., Henry, Scott P., Green, Ellen A.
Publicado em 2009

Predictive Dose-Based Estimation of Systemic Exposure Multiples in Mouse and Monkey Relative to Human for Antisense Oligonucleotides With 2′-O-(2-Methoxyethyl) Modifications

Por Yu, Rosie Z, Grundy, John S, Henry, Scott P, Kim, Tae-Won, Norris, Daniel A, Burkey, Jennifer, Wang, Yanfeng, Vick, Andrew, Geary, Richard S
Publicado no Mol Ther Nucleic Acids (2015)

Reduction in ocular complement factor B protein in mice and monkeys by systemic administration of factor B antisense oligonucleotide

Por Grossman, Tamar R., Carrer, Michele, Shen, Lijiang, Johnson, Robert B., Hettrick, Lisa A., Henry, Scott P., Monia, Brett P., McCaleb, Michael L.
Publicado no Mol Vis (2017)

Assessment of the Drug Interaction Potential of Unconjugated and GalNAc(3)-Conjugated 2′-MOE-ASOs

Por Shemesh, Colby S., Yu, Rosie Z., Warren, Mark S., Liu, Michael, Jahic, Mirza, Nichols, Brandon, Post, Noah, Lin, Song, Norris, Daniel A., Hurh, Eunju, Huang, Jane, Watanabe, Tanya, Henry, Scott P., Wang, Yanfeng
Publicado no Mol Ther Nucleic Acids (2017)

Pharmacology of a Central Nervous System Delivered 2′-O-Methoxyethyl–Modified Survival of Motor Neuron Splicing Oligonucleotide in Mice and Nonhuman Primates

Por Rigo, Frank, Chun, Seung J., Norris, Daniel A., Hung, Gene, Lee, Sam, Matson, John, Fey, Robert A., Gaus, Hans, Hua, Yimin, Grundy, John S., Krainer, Adrian R., Henry, Scott P., Bennett, C. Frank
Publicado em 2014

Elucidation of the Biotransformation Pathways of a Galnac(3)-conjugated Antisense Oligonucleotide in Rats and Monkeys

Por Shemesh, Colby S, Yu, Rosie Z, Gaus, Hans J, Greenlee, Sarah, Post, Noah, Schmidt, Karsten, Migawa, Michael T, Seth, Punit P, Zanardi, Thomas A, Prakash, Thazha P, Swayze, Eric E, Henry, Scott P, Wang, Yanfeng
Publicado no Mol Ther Nucleic Acids (2016)

Integrated Safety Assessment of 2′-O-Methoxyethyl Chimeric Antisense Oligonucleotides in NonHuman Primates and Healthy Human Volunteers

Por Crooke, Stanley T, Baker, Brenda F, Kwoh, T Jesse, Cheng, Wei, Schulz, Dan J, Xia, Shuting, Salgado, Nelson, Bui, Huynh-Hoa, Hart, Christopher E, Burel, Sebastien A, Younis, Husam S, Geary, Richard S, Henry, Scott P, Bhanot, Sanjay
Publicado no Mol Ther (2016)

Inhibiting C-Reactive Protein for the Treatment of Cardiovascular Disease: Promising Evidence from Rodent Models

Por Szalai, Alexander J., McCrory, Mark A., Xing, Dongqi, Hage, Fadi G., Miller, Andrew, Oparil, Suzanne, Chen, Yiu-Fai, Mazzone, Michelle, Early, Richard, Henry, Scott P., Zanardi, Thomas A., Graham, Mark J., Crooke, Rosanne M.
Publicado em 2014

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

Por Burel, Sebastien A., Hart, Christopher E., Cauntay, Patrick, Hsiao, Jill, Machemer, Todd, Katz, Melanie, Watt, Andy, Bui, Huynh-hoa, Younis, Husam, Sabripour, Mahyar, Freier, Susan M., Hung, Gene, Dan, Amy, Prakash, T.P., Seth, Punit P., Swayze, Eric E., Bennett, C. Frank, Crooke, Stanley T., Henry, Scott P.
Publicado no Nucleic Acids Res (2016)