Reduction in ocular complement factor B protein in mice and monkeys by systemic administration of factor B antisense oligonucleotide

PURPOSE: Age-related macular degeneration (AMD) is the leading cause of permanent vision loss among the elderly in many industrialized countries, and the complement system plays an important role in the pathogenesis of AMD. Inhibition of complement factor B, a key regulator of the alternative pathwa...

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Detalhes bibliográficos
Publicado no:Mol Vis
Main Authors: Grossman, Tamar R., Carrer, Michele, Shen, Lijiang, Johnson, Robert B., Hettrick, Lisa A., Henry, Scott P., Monia, Brett P., McCaleb, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: Molecular Vision 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5563462/
https://ncbi.nlm.nih.gov/pubmed/28855795
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