Antisense oligonucleotide treatment ameliorates alpha-1 antitrypsin–related liver disease in mice

Alpha-1 antitrypsin deficiency (AATD) is a rare genetic disease that results from mutations in the alpha-1 antitrypsin (AAT) gene. The mutant AAT protein aggregates and accumulates in the liver leading to AATD liver disease, which is only treatable by liver transplant. The PiZ transgenic mouse strai...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Guo, Shuling, Booten, Sheri L., Aghajan, Mariam, Hung, Gene, Zhao, Chenguang, Blomenkamp, Keith, Gattis, Danielle, Watt, Andrew, Freier, Susan M., Teckman, Jeffery H., McCaleb, Michael L., Monia, Brett P.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2013
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3871221/
https://ncbi.nlm.nih.gov/pubmed/24355919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67968
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia