Knockdown of Alpha-1 Antitrypsin with antisense oligonucleotide does not exacerbate smoke induced lung injury

Alpha-1 Antitrypsin (AAT) is a serum protease inhibitor that regulates increased lung protease production induced by cigarette smoking. Mutations in the Serpina1 gene cause AAT to form hepatoxic polymers, which can lead to reduced availability for the protein’s primary function and severe liver dise...

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Publicat a:PLoS One
Autors principals: Stearns, Kyle, Goldklang, Monica, Xiao, Rui, Zelonina, Tina, Blomenkamp, Keith, Teckman, Jeffery, D’Armiento, Jeanine M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7861354/
https://ncbi.nlm.nih.gov/pubmed/33539438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0246040
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