Knockdown of Alpha-1 Antitrypsin with antisense oligonucleotide does not exacerbate smoke induced lung injury

Alpha-1 Antitrypsin (AAT) is a serum protease inhibitor that regulates increased lung protease production induced by cigarette smoking. Mutations in the Serpina1 gene cause AAT to form hepatoxic polymers, which can lead to reduced availability for the protein’s primary function and severe liver dise...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Stearns, Kyle, Goldklang, Monica, Xiao, Rui, Zelonina, Tina, Blomenkamp, Keith, Teckman, Jeffery, D’Armiento, Jeanine M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7861354/
https://ncbi.nlm.nih.gov/pubmed/33539438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0246040
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker