Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell Degeneration

PURPOSE: To preserve photoreceptor cell structure and function in a rodent model of retinitis pigmentosa with P23H rhodopsin by selective inhibition of the mutant rhodopsin allele using a second generation antisense oligonucleotide (ASO). METHODS: Wild-type mice and rats were treated with ASO by int...

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Detalhes bibliográficos
Publicado no:Invest Ophthalmol Vis Sci
Main Authors: Murray, Susan F., Jazayeri, Ali, Matthes, Michael T., Yasumura, Douglas, Yang, Haidong, Peralta, Raechel, Watt, Andy, Freier, Sue, Hung, Gene, Adamson, Peter S., Guo, Shuling, Monia, Brett P., LaVail, Matthew M., McCaleb, Michael L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Association for Research in Vision and Ophthalmology 2015
Assuntos:
Biochemistry and Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104522/
https://ncbi.nlm.nih.gov/pubmed/26436889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-16400
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