Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell Degeneration

PURPOSE: To preserve photoreceptor cell structure and function in a rodent model of retinitis pigmentosa with P23H rhodopsin by selective inhibition of the mutant rhodopsin allele using a second generation antisense oligonucleotide (ASO). METHODS: Wild-type mice and rats were treated with ASO by int...

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Foilsithe in:Invest Ophthalmol Vis Sci
Main Authors: Murray, Susan F., Jazayeri, Ali, Matthes, Michael T., Yasumura, Douglas, Yang, Haidong, Peralta, Raechel, Watt, Andy, Freier, Sue, Hung, Gene, Adamson, Peter S., Guo, Shuling, Monia, Brett P., LaVail, Matthew M., McCaleb, Michael L.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The Association for Research in Vision and Ophthalmology 2015
Ábhair:
Biochemistry and Molecular Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104522/
https://ncbi.nlm.nih.gov/pubmed/26436889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-16400
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