Allele-Specific Inhibition of Rhodopsin With an Antisense Oligonucleotide Slows Photoreceptor Cell Degeneration

PURPOSE: To preserve photoreceptor cell structure and function in a rodent model of retinitis pigmentosa with P23H rhodopsin by selective inhibition of the mutant rhodopsin allele using a second generation antisense oligonucleotide (ASO). METHODS: Wild-type mice and rats were treated with ASO by int...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Invest Ophthalmol Vis Sci
Asıl Yazarlar: Murray, Susan F., Jazayeri, Ali, Matthes, Michael T., Yasumura, Douglas, Yang, Haidong, Peralta, Raechel, Watt, Andy, Freier, Sue, Hung, Gene, Adamson, Peter S., Guo, Shuling, Monia, Brett P., LaVail, Matthew M., McCaleb, Michael L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Association for Research in Vision and Ophthalmology 2015
Konular:
Biochemistry and Molecular Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104522/
https://ncbi.nlm.nih.gov/pubmed/26436889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.15-16400
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller