Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

β-Thalassemia and HFE-related hemochromatosis are 2 of the most frequently inherited disorders worldwide. Both disorders are characterized by low levels of hepcidin (HAMP), the hormone that regulates iron absorption. As a consequence, patients affected by these disorders exhibit iron overload, which...

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Bibliografski detalji
Glavni autori: Guo, Shuling, Casu, Carla, Gardenghi, Sara, Booten, Sheri, Aghajan, Mariam, Peralta, Raechel, Watt, Andy, Freier, Sue, Monia, Brett P., Rivella, Stefano
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2013
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3613931/
https://ncbi.nlm.nih.gov/pubmed/23524968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66969
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