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Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice
β-Thalassemia and HFE-related hemochromatosis are 2 of the most frequently inherited disorders worldwide. Both disorders are characterized by low levels of hepcidin (HAMP), the hormone that regulates iron absorption. As a consequence, patients affected by these disorders exhibit iron overload, which...
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| Asıl Yazarlar: | , , , , , , , , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Clinical Investigation
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3613931/ https://ncbi.nlm.nih.gov/pubmed/23524968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66969 |
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