β-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload

Por Melchiori, Luca, Gardenghi, Sara, Rivella, Stefano
Publicado em 2010

Anemia, Ineffective Erythropoiesis and Hepcidin: Interacting Factors in Abnormal Iron Metabolism Leading to Iron Overload in β-Thalassemia

Por Gardenghi, Sara, Grady, Robert W., Rivella, Stefano
Publicado em 2010

Iron metabolism and ineffective erythropoiesis in β-thalassemia mouse models

Por Ramos, Pedro, Melchiori, Luca, Gardenghi, Sara, Van-Roijen, Nico, Grady, Robert W., Ginzburg, Yelena, Rivella, Stefano
Publicado em 2010

Hepcidin and Hfe in iron overload in β-thalassemia

Por Gardenghi, Sara, Ramos, Pedro, Follenzi, Antonia, Rao, Niva, Rachmilewitz, Eliezer A., Giardina, Patricia J., Grady, Robert W., Rivella, Stefano
Publicado em 2010

Reducing TMPRSS6 ameliorates hemochromatosis and β-thalassemia in mice

Por Guo, Shuling, Casu, Carla, Gardenghi, Sara, Booten, Sheri, Aghajan, Mariam, Peralta, Raechel, Watt, Andy, Freier, Sue, Monia, Brett P., Rivella, Stefano
Publicado em 2013

Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt

Por Han, Chang Yeob, Koo, Ja Hyun, Kim, Sung Hoon, Gardenghi, Sara, Rivella, Stefano, Strnad, Pavel, Hwang, Se Jin, Kim, Sang Geon
Publicado no Nat Commun (2016)

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction

Por Zuccato, Cristina, Breda, Laura, Salvatori, Francesca, Breveglieri, Giulia, Gardenghi, Sara, Bianchi, Nicoletta, Brognara, Eleonora, Lampronti, Ilaria, Borgatti, Monica, Rivella, Stefano, Gambari, Roberto
Publicado em 2012

Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response

Por Richardson, Chanté L., Delehanty, Lorrie L., Bullock, Grant C., Rival, Claudia M., Tung, Kenneth S., Kimpel, Donald L., Gardenghi, Sara, Rivella, Stefano, Goldfarb, Adam N.
Publicado em 2013

Intestinal HIF2α promotes tissue-iron accumulation in disorders of iron overload with anemia

Por Anderson, Erik R., Taylor, Matthew, Xue, Xiang, Ramakrishnan, Sadeesh K., Martin, Angelical, Xie, Liwei, Bredell, Bryce X., Gardenghi, Sara, Rivella, Stefano, Shah, Yatrik M.
Publicado em 2013

Distinct roles for hepcidin and interleukin-6 in the recovery from anemia in mice injected with heat-killed Brucella abortus

Por Gardenghi, Sara, Renaud, Tom M., Meloni, Alessandra, Casu, Carla, Crielaard, Bart J., Bystrom, Laura M., Greenberg-Kushnir, Noa, Sasu, Barbra J., Cooke, Keegan S., Rivella, Stefano
Publicado em 2014

Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis

Por Ramos, Pedro, Guy, Ella, Chen, Nan, Proenca, Catia C., Gardenghi, Sara, Casu, Carla, Follenzi, Antonia, Van Rooijen, Nico, Grady, Robert W., de Sousa, Maria, Rivella, Stefano
Publicado em 2011

Modified activin receptor IIB ligand trap mitigates ineffective erythropoiesis and disease complications in murine β-thalassemia

Por Suragani, Rajasekhar N. V. S., Cawley, Sharon M., Li, Robert, Wallner, Samantha, Alexander, Mark J., Mulivor, Aaron W., Gardenghi, Sara, Rivella, Stefano, Grinberg, Asya V., Pearsall, R. Scott, Kumar, Ravindra
Publicado em 2014

Therapeutic Hemoglobin Levels after Gene Transfer in β-Thalassemia Mice and in Hematopoietic Cells of β-Thalassemia and Sickle Cells Disease Patients

Por Breda, Laura, Casu, Carla, Gardenghi, Sara, Bianchi, Nicoletta, Cartegni, Luca, Narla, Mohandas, Yazdanbakhsh, Karina, Musso, Marco, Manwani, Deepa, Little, Jane, Gardner, Lawrence B., Kleinert, Dorothy A., Prus, Eugenia, Fibach, Eitan, Grady, Robert W., Giardina, Patricia J., Gambari, Roberto, Rivella, Stefano
Publicado em 2012

Macrophages support pathological erythropoiesis in Polycythemia Vera and Beta-Thalassemia

Por Ramos, Pedro, Casu, Carla, Gardenghi, Sara, Breda, Laura, Crielaard, Bart J., Guy, Ella, Marongiu, Maria Franca, Gupta, Ritama, Levine, Ross L., Abdel-Wahab, Omar, Ebert, Benjamin L., Van Rooijen, Nico, Ghaffari, Saghi, Grady, Robert W., Giardina, Patricia J., Rivella, Stefano
Publicado em 2013

Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice

Por Gardenghi, Sara, Ramos, Pedro, Marongiu, Maria Franca, Melchiori, Luca, Breda, Laura, Guy, Ella, Muirhead, Kristen, Rao, Niva, Roy, Cindy N., Andrews, Nancy C., Nemeth, Elizabeta, Follenzi, Antonia, An, Xiuli, Mohandas, Narla, Ginzburg, Yelena, Rachmilewitz, Eliezer A., Giardina, Patricia J., Grady, Robert W., Rivella, Stefano
Publicado em 2010

HMGB1 Mediates Anemia of Inflammation in Murine Sepsis Survivors

Por Valdés-Ferrer, Sergio I, Papoin, Julien, Dancho, Meghan E, Olofsson, Peder S, Li, Jianhua, Lipton, Jeffrey M, Avancena, Patricia, Yang, Huan, Zou, Yong-Rui, Chavan, Sangeeta S, Volpe, Bruce T, Gardenghi, Sara, Rivella, Stefano, Diamond, Betty, Andersson, Ulf, Steinberg, Bettie M, Blanc, Lionel, Tracey, Kevin J
Publicado no Mol Med (2015)

Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

Por Gardenghi, Sara, Marongiu, Maria F., Ramos, Pedro, Guy, Ella, Breda, Laura, Chadburn, Amy, Liu, YiFang, Amariglio, Ninette, Rechavi, Gideon, Rachmilewitz, Eliezer A., Breuer, William, Cabantchik, Z. Ioav, Wrighting, Diedra M., Andrews, Nancy C., de Sousa, Maria, Giardina, Patricia J., Grady, Robert W., Rivella, Stefano
Publicado em 2007