Hepcidin and Hfe in iron overload in β-thalassemia

Hepcidin (HAMP) negatively regulates iron absorption, degrading the iron exporter ferroportin at the level of enterocytes and macrophages. We showed that mice with β-thalassemia intermedia (th3/+) have increased anemia and iron overload. However, their hepcidin expression is relatively low compared...

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Hauptverfasser: Gardenghi, Sara, Ramos, Pedro, Follenzi, Antonia, Rao, Niva, Rachmilewitz, Eliezer A., Giardina, Patricia J., Grady, Robert W., Rivella, Stefano
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652388/
https://ncbi.nlm.nih.gov/pubmed/20712796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1749-6632.2010.05595.x
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