Ineffective erythropoiesis in β-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin

Progressive iron overload is the most salient and ultimately fatal complication of β-thalassemia. However, little is known about the relationship among ineffective erythropoiesis (IE), the role of iron-regulatory genes, and tissue iron distribution in β-thalassemia. We analyzed tissue iron content a...

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Main Authors: Gardenghi, Sara, Marongiu, Maria F., Ramos, Pedro, Guy, Ella, Breda, Laura, Chadburn, Amy, Liu, YiFang, Amariglio, Ninette, Rechavi, Gideon, Rachmilewitz, Eliezer A., Breuer, William, Cabantchik, Z. Ioav, Wrighting, Diedra M., Andrews, Nancy C., de Sousa, Maria, Giardina, Patricia J., Grady, Robert W., Rivella, Stefano
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2007
Teme:
Red Cells
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1885515/
https://ncbi.nlm.nih.gov/pubmed/17299088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-09-048868
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