Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in β-thalassemia

In β-thalassemia, the mechanism driving ineffective erythropoiesis (IE) is insufficiently understood. We analyzed mice affected by β-thalassemia and observed, unexpectedly, a relatively small increase in apoptosis of their erythroid cells compared with healthy mice. Therefore, we sought to determine...

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Détails bibliographiques
Auteurs principaux: Libani, Ilaria V., Guy, Ella C., Melchiori, Luca, Schiro, Raffaella, Ramos, Pedro, Breda, Laura, Scholzen, Thomas, Chadburn, Amy, Liu, YiFang, Kernbach, Margrit, Baron-Lühr, Bettina, Porotto, Matteo, de Sousa, Maria, Rachmilewitz, Eliezer A., Hood, John D., Cappellini, M. Domenica, Giardina, Patricia J., Grady, Robert W., Gerdes, Johannes, Rivella, Stefano
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2008
Sujets:
Red Cells
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2481539/
https://ncbi.nlm.nih.gov/pubmed/18480424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-12-126938
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