Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis

In hereditary hemochromatosis, mutations in HFE lead to iron overload through abnormally low levels of hepcidin. In addition, HFE potentially modulates cellular iron uptake by interacting with transferrin receptor, a crucial protein during erythropoiesis. However, the role of HFE in this process was...

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Detaylı Bibliyografya
Asıl Yazarlar: Ramos, Pedro, Guy, Ella, Chen, Nan, Proenca, Catia C., Gardenghi, Sara, Casu, Carla, Follenzi, Antonia, Van Rooijen, Nico, Grady, Robert W., de Sousa, Maria, Rivella, Stefano
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Hematology 2011
Konular:
Red Cells, Iron, and Erythropoiesis
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056475/
https://ncbi.nlm.nih.gov/pubmed/21059897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-307462
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