Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis

In hereditary hemochromatosis, mutations in HFE lead to iron overload through abnormally low levels of hepcidin. In addition, HFE potentially modulates cellular iron uptake by interacting with transferrin receptor, a crucial protein during erythropoiesis. However, the role of HFE in this process was...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Ramos, Pedro, Guy, Ella, Chen, Nan, Proenca, Catia C., Gardenghi, Sara, Casu, Carla, Follenzi, Antonia, Van Rooijen, Nico, Grady, Robert W., de Sousa, Maria, Rivella, Stefano
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society of Hematology 2011
Θέματα:
Red Cells, Iron, and Erythropoiesis
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056475/
https://ncbi.nlm.nih.gov/pubmed/21059897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-307462
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