Enhanced erythropoiesis in Hfe-KO mice indicates a role for Hfe in the modulation of erythroid iron homeostasis

In hereditary hemochromatosis, mutations in HFE lead to iron overload through abnormally low levels of hepcidin. In addition, HFE potentially modulates cellular iron uptake by interacting with transferrin receptor, a crucial protein during erythropoiesis. However, the role of HFE in this process was...

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Autors principals: Ramos, Pedro, Guy, Ella, Chen, Nan, Proenca, Catia C., Gardenghi, Sara, Casu, Carla, Follenzi, Antonia, Van Rooijen, Nico, Grady, Robert W., de Sousa, Maria, Rivella, Stefano
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2011
Matèries:
Red Cells, Iron, and Erythropoiesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3056475/
https://ncbi.nlm.nih.gov/pubmed/21059897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-307462
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