Hepcidin inhibits Smad3 phosphorylation in hepatic stellate cells by impeding ferroportin-mediated regulation of Akt

Hepatic stellate cell (HSC) activation on liver injury facilitates fibrosis. Hepatokines affecting HSCs are largely unknown. Here we show that hepcidin inhibits HSC activation and ameliorates liver fibrosis. We observe that hepcidin levels are inversely correlated with exacerbation of fibrosis in pa...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Han, Chang Yeob, Koo, Ja Hyun, Kim, Sung Hoon, Gardenghi, Sara, Rivella, Stefano, Strnad, Pavel, Hwang, Se Jin, Kim, Sang Geon
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5192182/
https://ncbi.nlm.nih.gov/pubmed/28004654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms13817
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