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Pharmacological Targeting of the Hepcidin/Ferroportin Axis
The iron regulatory hormone hepcidin limits iron fluxes to the bloodstream by promoting degradation of the iron exporter ferroportin in target cells. Hepcidin insufficiency causes hyperabsorption of dietary iron, hyperferremia and tissue iron overload, which are hallmarks of hereditary hemochromatos...
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| Publicado no: | Front Pharmacol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4914558/ https://ncbi.nlm.nih.gov/pubmed/27445804 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00160 |
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