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Pharmacological Targeting of the Hepcidin/Ferroportin Axis

The iron regulatory hormone hepcidin limits iron fluxes to the bloodstream by promoting degradation of the iron exporter ferroportin in target cells. Hepcidin insufficiency causes hyperabsorption of dietary iron, hyperferremia and tissue iron overload, which are hallmarks of hereditary hemochromatos...

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Bibliografski detalji
Izdano u:Front Pharmacol
Glavni autori: Sebastiani, Giada, Wilkinson, Nicole, Pantopoulos, Kostas
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914558/
https://ncbi.nlm.nih.gov/pubmed/27445804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2016.00160
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