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The Role of Ubiquitination in Hepcidin-Independent and Hepcidin-Dependent Degradation of Ferroportin
The iron exporter ferroportin (Fpn) is essential to transfer iron from cells to plasma. Systemic iron homeostasis in vertebrates is regulated by the hepcidin-mediated internalization of Fpn. Here we demonstrate a second route for Fpn internalization, when cytosolic iron levels are low Fpn is interna...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3229915/ https://ncbi.nlm.nih.gov/pubmed/22019085 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2011.09.008 |
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