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Human mutation D157G in ferroportin leads to hepcidin-independent binding of Jak2 and ferroportin down-regulation
Mutations in the iron exporter ferroportin (Fpn) result in iron overload in macrophages or hepatocytes depending upon the mutation. Patients with Fpn mutation D157G show high serum ferritin and normal to slightly elevated transferrin saturation. Here, we show that Fpn(D157G)–green fluorescent protei...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society of Hematology
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2854436/ https://ncbi.nlm.nih.gov/pubmed/20124516 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-251306 |
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