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Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2
Hepcidin is a hormone secreted in response to iron loading and inflammation. Hepcidin binds to the iron exporter ferroportin, inducing its degradation and thus preventing iron entry into plasma. We determined that hepcidin binding to ferroportin leads to the binding and activation of the protein Jan...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2656160/ https://ncbi.nlm.nih.gov/pubmed/19234114 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0900453106 |
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