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The hepcidin-binding site on ferroportin is evolutionarily conserved
Mammalian iron homeostasis is regulated by the interaction of the liver-produced peptide hepcidin and its receptor, the iron transporter ferroportin. Hepcidin binds to ferroportin resulting in degradation of ferroportin and decreased cellular iron export. We identify the hepcidin-binding domain (HBD...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2660598/ https://ncbi.nlm.nih.gov/pubmed/18680715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.07.002 |
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