The hepcidin-binding site on ferroportin is evolutionarily conserved

Mammalian iron homeostasis is regulated by the interaction of the liver-produced peptide hepcidin and its receptor, the iron transporter ferroportin. Hepcidin binds to ferroportin resulting in degradation of ferroportin and decreased cellular iron export. We identify the hepcidin-binding domain (HBD...

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Main Authors: De Domenico, Ivana, Nemeth, Elizabeta, Nelson, Jenifer M., Phillips, John D., Ajioka, Richard S., Kay, Michael S., Kushner, James P., Ganz, Tomas, Ward, Diane M., Kaplan, Jerry
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2660598/
https://ncbi.nlm.nih.gov/pubmed/18680715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2008.07.002
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