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The Molecular Mechanism of Hepcidin-mediated Ferroportin Down-Regulation
Ferroportin (Fpn) is the only known iron exporter in vertebrates. Hepcidin, a peptide secreted by the liver in response to iron or inflammation, binds to Fpn, inducing its internalization and degradation. We show that after binding of hepcidin, Fpn is tyrosine phosphorylated at the plasma membrane....
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The American Society for Cell Biology
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1924807/ https://ncbi.nlm.nih.gov/pubmed/17475779 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-01-0060 |
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