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Human mutation D157G in ferroportin leads to hepcidin-independent binding of Jak2 and ferroportin down-regulation

Mutations in the iron exporter ferroportin (Fpn) result in iron overload in macrophages or hepatocytes depending upon the mutation. Patients with Fpn mutation D157G show high serum ferritin and normal to slightly elevated transferrin saturation. Here, we show that Fpn(D157G)–green fluorescent protei...

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Bibliografiska uppgifter
Huvudupphovsmän: De Domenico, Ivana, Lo, Eric, Ward, Diane M., Kaplan, Jerry
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854436/
https://ncbi.nlm.nih.gov/pubmed/20124516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-10-251306
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